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aryl hydrocarbon receptor nuclear translocator; ARNT protein; class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta (ARNT, BHLHE2)

See Ah receptor complex Function: - Ah receptor binds to DNA as heterodimer with ARNT - required for activity of the Ah (dioxin) receptor - required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding - the complex then initiates transcription of genes involved in activation of PAH procarcinogens - heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia - efficient DNA binding requires dimerization with another bHLH protein - forms a heterodimer with AHR, AHRR, HIF1A & EPAS1/HIF2A as well as with other bHLH proteins - interacts with TACC3 (putative) - interacts with NOCA7 - heterodimer with HIF1A Structure: - contains 1 basic helix-loop-helix (bHLH) domain - contains 1 PAC (PAS-associated C-terminal) domain - contains 2 PAS (PER-ARNT-SIM) domains Compartment: nucleus Alternative splicing: named isoforms=3

Interactions

molecular events

Related

aromatic hydrocarbon aryl hydrocarbon [Ah] receptor complex hypoxia inducible factor 1

General

basic helix loop helix (bHLH) family transcription factor phosphoprotein

Properties

SIZE: entity length = 789 aa MW = 87 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S77} DNA-binding motif SITE: 90-102 MOTIF: arginine-rich region {99-102} MOTIF: arginine residue (SEVERAL) helix-loop-helix NAME: helix-loop-helix SITE: 103-143 FOR-BINDING-VIA: helix-loop-helix PAS domain {161-235} PAS domain {349-419} PAC domain {424-467} glutamine-rich region {503-507} MOTIF: glutamine residue (SEVERAL) glutamine-rich region {710-769} MOTIF: glutamine residue (SEVERAL) serine-rich region {738-741} MOTIF: serine residue (SEVERAL)

References

  1. UniProt :accession P27540
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/ARNTID223ch1q21.html
  3. NIEHS-SNPs http://egp.gs.washington.edu/data/arnt/
  4. Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA, Hankinson O. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science. 1991 May 17;252(5008):954-8. PMID: 1852076

Component-of

molecular complex

Databases & Figures

OMIM 126110 UniProt P27540 PFAM correlations Entrez Gene 405 Kegg hsa:405 HIF-1 pathway