arylsulfatase-E (ARSE)

Function: - may be essential for the correct composition of cartilage & bone matrix during development - no activity toward steroid sulfates - inhibited by millimolar concentrations of warfarin Cofactor: - binds 1 Ca⁺² per subunit (putative) Kinetic parameters: - Optimum pH is 7 - Temperature dependence: - almost completely inactivated after 10 minutes at 50 degrees C Structure: - belongs to the sulfatase family - N-glycosylated Compartment: Golgi apparatus, Golgi stack Expression: expressed in the pancreas, liver & kidney Pathology: - defects in ARSE are the cause of X-linked recessive chondrodysplasia punctata 1

General

arylsulfatase hydrolase

Properties

SIZE: entity length = 589 aa MW = 66 kD COMPARTMENT: golgi MOTIF: signal sequence {1-31} Ca+2-binding site SITE: 46-46 Ca+2-binding site SITE: 47-47 N-glycosylation site {N58} Ca+2-binding site SITE: 86-86 N-glycosylation site {N125} histidine residue {H147} N-glycosylation site {N258} N-glycosylation site {N344} Ca+2-binding site SITE: 353-353 Ca+2-binding site SITE: 354-354

Database Correlations

OMIM correlations UniProt P51690 Pfam PF00884 Entrez Gene 415 Kegg hsa:415