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artemin; enovin; neublastin (ARTN, EVN)
Function:
1) ligand for GFR-alpha-3-RET receptor complex
2) also activate the GFR-alpha-1-RET receptor complex
3) supports survival of sensory & sympathetic peripheral neurons in culture
4) supports survival of dopaminergic neurons of ventral mid-brain (substantia nigra)
Structure:
1) homodimer, disulfide-linked
2) belongs to the TGF-beta family, GDNF subfamily
Compartment: secreted
Alternative splicing: named isoforms=3
Expression:
- ubiquitous
- expressed in prostate, placenta, pancreas, heart, kidney, pituitary, lung, testis > brain
- expressed during embryogenesis
- expression seen in fetal kidney, lung > fetal brain
General
secreted protein
Properties
SIZE: MW = 23 kD
entity length = 220 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-39}
proline-rich region
SITE: 45-100
MOTIF: proline residue (SEVERAL)
cysteine residue {C123}
MODIFICATION: cysteine residue {C188}
cysteine residue {C150}
MODIFICATION: cysteine residue {C216}
cysteine residue {C154}
MODIFICATION: cysteine residue {C218}
cysteine residue {C187}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C188}
MODIFICATION: cysteine residue {C123}
N-glycosylation site {N202}
cysteine residue {C216}
MODIFICATION: cysteine residue {C150}
cysteine residue {C218}
MODIFICATION: cysteine residue {C154}
Database Correlations
OMIM 603886
UniProt Q5T4W7
Pfam PF00019
References
UniProt :accession Q5T4W7