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arsenic trioxide; As2O3 (Trisenox)
Tradename: Trisenox. (As2O3)
Indications:
- treatment of acute promyelocytic leukemia
- treatment of acute myelomonocytic leukemia [3,4]
- treatment of myelodysplastic syndrome [2]
Dosage:
- injectable arsenic
Monitor:
- electrocardiogram: QT interval [5]
Pharmacokinetics:
- within 24 hours, arsenic is distributed to all body tissues
- the major route of excretion is through the kidneys
- arsenic crosses the placenta
Adverse effects:
- see arsenic poisoning
- prolongation of QT interval [5]
Related
arsenic poisoning
arsenic [As]
As+3 (trivalent arsenic)
General
antineoplastic agent (chemotherapeutic agent)
oxide
Database Correlations
PUBCHEM correlations
References
- Prescriber's Letter 8(2):supplement 2001
- Deprecated Reference
- Powell BL, Moser B, Stock W, Gallagher RE et al
Arsenic trioxide improves event-free and overall survival for
adults with acute promyelocytic leukemia: North American
Leukemia Intergroup Study C9710.
Blood. 2010 Nov 11;116(19):3751-7.
PMID: 20705755
- Lo-Coco F, Avvisati G, Vignetti M et al
Retinoic acid and arsenic trioxide for acute promyelocytic
leukemia.
N Engl J Med. 2013 Jul 11;369(2):111-21.
PMID: 23841729
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015