Arp2/3 inhibition protein (ARPIN C15orf38)

Function: - regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex - function is competetive with nucleation promoting factors - participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling & where Rac also stimulates actin polymerization through the WAVE complex - involved in steering cell migration by controlling its directional persistence - associates with the Arp2/3 complex - interacts with ARPC2 - enhanced by activated RAC1 - interacts with ARPC5; interaction is dependent on RAC1 Structure: - the acidic C-terminus is necessary & sufficient to inhibit ARP2/3 complex activity - belongs to the Arpin family Compartment: - cell projection, lamellipodium - colocalized with the WAVE complex at lamelliupodium tip (putative) Alternative splicing: named isoforms=2 Note: - based on a naturally occurring readthrough transcript which produces a C15orf38-AP3S2 fusion protein

Properties

SIZE: entity length = 226 aa MW = 25 kD COMPARTMENT: cytoplasm MOTIF: Necessary and sufficient for interaction with ARPC2 {211-226}

Database Correlations

UniProt Q7Z6K5 Pfam PF10574 LOCUS-LINK correlations KEGG correlations

References

UniProt :accession Q7Z6K5