armadillo repeat-containing protein 10 (splicing variant involved in hepatocarcinogenesis protein, ARMC10, SVH, PSEC0198)

Function: - role in cell survival & cell growth (putative) Structure: contains 1 ARM repeat Compartment: endoplasmic reticulum membrane Alternative splicing: named isoforms=4 Expression: - expressed in all tissues tested - higher expression in placenta, liver, kidney, heart & brain Pathology: - depletion of isoform 2 results in cell apoptosis - overexpression of isoform 2 leads to accelerated growth rate & tumorogenicity

General

armadillo repeat-containing X-linked protein glycoprotein membrane protein phosphoprotein

Properties

SIZE: entity length = 343 aa MW = 38 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {5-27} Ser phosphorylation site {S45} ARM repeat {138-180} MOTIF: N-glycosylation site {N164} N-glycosylation site {N205} N-glycosylation site {N244}

Database Correlations

UniProt Q8N2F6 Pfam PF04826

References

UniProt :accession Q8N2F6