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ariadne-2 protein homolog; ARI-2; triad1 protein (ARIH2, ARI2, TRIAD1, HT005)
Function:
- might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, & then transfers it to substrates
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with UBE2L3 (putative)
Structure:
- belongs to the RBR family, Ariadne subfamily
- contains 1 IBR-type Zn+2 finger
- contains 2 RING-type Zn+2 fingers
Compartment: nucleus
Related
ubiquitin (UBCEP2, UBB, UBC)
General
nuclear protein
phosphoprotein
ring finger protein
Properties
SIZE: entity length = 493 aa
MW = 58 kD
COMPARTMENT: cell nucleus
MOTIF: acidic region {4-75}
MOTIF: acidic residue (SEVERAL)
glutamate-rich region {22-29}
MOTIF: glutamate residue (SEVERAL)
RING-finger {139-188}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger
SITE: 208-270
EFFECTOR-BOUND: Zn+2
RING-finger {297-326}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S353}
coiled coil {369-400}
coiled coil {439-492}
Database Correlations
OMIM 605615
UniProt O95376
Pfam PF01485
Entrez Gene 10425
Kegg hsa:10425
References
- UniProt :accession O95376
- Entrez Gene :accession 10425