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ARHGEF5 (rho guanine nucleotide exchange factor 5) gene (transforming immortalized mammary oncogene, TIM)
A segmental duplication of chromosome 7 involving ARHGEF5 is one of the few features distinguishing the human genome from the chimpanzee genome. [1]
Related
Rho guanine nucleotide exchange factor 5; ephexin-3; guanine nucleotide regulatory protein TIM; oncogene TIM; transforming immortalized mammary oncoprotein; p60 TIM (ARHGEF5, TIM)
General
evolutionary divergent human gene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: Rho guanine nucleotide exchange factor 5
LOCUS: human chromosome-7 Q33-35
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM 600888
Entrez Gene 7984
References
- Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L,
Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-
Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM.
Lineage-specific gene duplication and loss in human and great
ape evolution.
PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13.
PMID: 15252450