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arginase-1 (hepatic arginase, ARG1)
Contributes 98% of activity in liver
Function:
- nitrogen metabolism, urea cycle
- L-ornithine & urea from L-arginine: step 1/1
- 98% of arginase activity in liver
L-arginine + H2O L-ornithine + urea
Cofactor: Mn+2
Structure:
- homotrimer
- belongs to the arginase family
Compartment: cytoplasm
Alternative splicing: named isoforms=3
Expression: induced by arginine or homoarginine
Pathology:
- defects in ARG1 are the cause of argininemia
Interactions
molecular events
Related
arginase-1 in serum
urea cycle
General
arginase
urea cycle enzyme
Properties
SIZE: entity length = 322 aa
MW = 35 kD
COMPARTMENT: cytoplasm
CELL: hepatocyte
MOTIF: manganese [Mn]-binding site
SITE: 101-101
manganese [Mn]-binding site
SITE: 124-124
manganese [Mn]-binding site
SITE: 126-126
manganese [Mn]-binding site
SITE: 128-128
Ser phosphorylation site {S230}
manganese [Mn]-binding site
SITE: 232-232
manganese [Mn]-binding site
SITE: 234-234
Database Correlations
OMIM correlations
MORBIDMAP 608313
UniProt P05089
Pfam PF00491
Entrez Gene 383
ENZYME 3.5.3.1
References
- OMIM :accession 207800
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ARG1
- Wikipedia, Arginase entry
http://en.wikipedia.org/wiki/Arginase
- UniProt :accession P05089