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ARF GTPase-activating protein GIT2; ARF GAP GIT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2 (GIT2, KIAA0148)
Function:
- GTPase-activating protein for the ADP ribosylation factor family
- interacts with TGFB1I1 (putative)
- interacts with G protein-coupled receptor kinases
- associates with paxillin
- also interacts with PIX exchange factors
Structure:
- contains 3 ANK repeats
- contains 1 Arf-GAP domain
Alternative splicing: named isoforms=11
General
ankyrin repeat domain protein (ANKRD)
ADP-ribosylation factor GTPase activating protein (ARF-GAP)
receptor
zinc finger protein
Properties
SIZE: entity length = 759 aa
MW = 85 kD
COMPARTMENT: cytoplasm
MOTIF: Arf-GAP domain
NAME: Arf-GAP domain
SITE: 1-124
MOTIF: Zn finger C4-type
SITE: 11-34
EFFECTOR-BOUND: Zn+2
ankyrin repeat
NAME: ankyrin repeat
SITE: 132-161
ankyrin repeat
NAME: ankyrin repeat
SITE: 166-195
ankyrin repeat
NAME: ankyrin repeat
SITE: 199-228
Ser phosphorylation site {S394}
Ser phosphorylation site {S397}
Thr phosphorylation site {T401}
Ser phosphorylation site {S415}
Ser phosphorylation site {S418}
Ser phosphorylation site {S421}
Tyr phosphorylation site {Y484}
Thr phosphorylation site {T488}
Tyr phosphorylation site {Y492}
Ser phosphorylation site {S496}
Ser phosphorylation site {S559}
Ser phosphorylation site {S586}
Ser phosphorylation site {S614}
Database Correlations
OMIM 608564
UniProt Q14161
PFAM correlations
Entrez Gene 9815
Kegg hsa:9815
References
UniProt :accession Q14161