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aquaporin-8; AQP-8 (AQP8)
Function:
- forms a water-specific channel
- mercury-sensitive
- not permeable to glycerol or urea
Structure:
- aquaporins contain two tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
- belongs to the MIP/aquaporin (TC 1.A.8) family
Compartment: membrane
Expression: expressed only in pancreas & colon
General
aquaporin
glycoprotein
transmembrane 6 protein
Properties
SIZE: entity length = 261 aa
MW = 27 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-36}
transmembrane domain {37-57}
exoplasmic loop {58-84}
MOTIF: N-glycosylation site {N59}
transmembrane domain {85-105}
MOTIF: peptide motif {92-94}
cytoplasmic loop {106-107}
transmembrane domain {108-128}
exoplasmic loop {129-156}
MOTIF: N-glycosylation site {N139}
transmembrane domain {157-177}
cytoplasmic loop {178-183}
transmembrane domain {184-204}
exoplasmic loop {205-228}
MOTIF: peptide motif {210-212}
transmembrane domain {229-249}
cytoplasmic domain {250-261}
Database Correlations
OMIM 603750
UniProt O94778
Pfam PF00230
Entrez Gene 343
Kegg hsa:343
References
UniProt :accession O94778