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aquaporin-5; AQP-5 (AQP5)
Function:
- forms a water-specific channel
- implicated in the generation of saliva, tears, & pulmonary secretions
Structure:
- aquaporins contain two tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
- belongs to the MIP/aquaporin (TC 1.A.8) family
Compartment: membrane
General
aquaporin
glycoprotein
transmembrane 6 protein
Properties
SIZE: entity length = 265 aa
MW = 28 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-12}
transmembrane domain {13-33}
exoplasmic loop {34-36}
transmembrane domain {37-57}
cytoplasmic loop {58-87}
MOTIF: peptide motif {69-71}
transmembrane domain {88-108}
exoplasmic loop {109-126}
MOTIF: N-glycosylation site {N124}
N-glycosylation site {N125}
transmembrane domain {127-147}
cytoplasmic loop {148-161}
transmembrane domain {162-182}
exoplasmic loop {183-205}
MOTIF: peptide motif {185-187}
transmembrane domain {206-226}
cytoplasmic domain {227-265}
Database Correlations
OMIM 600442
UniProt P55064
Pfam PF00230
Entrez Gene 362
Kegg hsa:362
References
UniProt :accession P55064