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aprataxin & PNK-like factor (APLF C2orf13)
Function:
- role in single-strand & double-strand DNA break repair
- interacts with XRCC1
- may also interact with XRCC4 & XRCC5
- phosphorylated in an ATM-dependent manner upon double-strand DNA break
Structure:
- contains 2 C2H2-type zinc fingers
- contains 1 FHA-like domain mediates interaction with XRCC1 & XRCC4
Compartment:
- nucleus, cytoplasm
- colocalizes with XRCC1 at sites of DNA damage
General
C2H2 type zinc finger protein
nuclear protein
phosphoprotein
Properties
SIZE: MW = 57 kD
entity length = 511 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: forkhead-associated (FHA) domain {1-108}
Zn finger C2H2-type
SITE: 377-398
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 419-440
EFFECTOR-BOUND: Zn+2
coiled coil {487-511}
Database Correlations
UniProt Q8IW19
References
UniProt :accession Q8IW19