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APP secretase
One of the proteases that cleaves the amyloid precursor protein with with a the N-terminal fragment into the exoplasmic space. Concerted activity of the beta & gamma secretase also result in formation of the A4 amyloid peptide (A-beta). Cleavage by alpha- secretase precludes formation of A-beta.
Specific
APP alpha-secretase
APP beta-secretase or beta-site APP-cleaving enzyme (BACE)
APP gamma-secretase
General
biochemistry
References
- Selkoe DJ.
Alzheimer's disease: genes, proteins, and therapy.
Physiol Rev. 2001 Apr;81(2):741-66. Review.
PMID: 11274343