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APP C99 peptide fragment
C-terminal peptide fragment generated from the amyloid precursor protein (APP) by APP beta-secretase. It serves as a substrate for gamma-secretase with formation the A4 amyloid peptide (A-beta).
Interactions
molecular events
Related
amyloid precursor protein (APP) or A4/beta amyloid precursor protein
APP beta-secretase or beta-site APP-cleaving enzyme (BACE)
APP gamma-secretase
General
peptide
Properties
SIZE: entity length = 99 aa
References
- Selkoe DJ.
Alzheimer's disease: genes, proteins, and therapy.
Physiol Rev. 2001 Apr;81(2):741-66. Review.
PMID: 11274343