amyloid beta precursor protein binding protein 1; NEDD8-activating enzyme E1 regulatory subunit; amyloid protein-binding protein 1; amyloid beta precursor protein-binding protein 1 59 kD; APP-binding protein 1; APP-BP1; protooncogene protein 1 (NAE1, HPP1, APPBP1)

Function: 1) protein neddylation 2) regulatory subunit of the dimeric UBE1C-APPBP1 E1 enzyme a) NEDD8 conjugation, 1st step b) transfers NEDD8 to the catalytic Cys of UBE2M 3) cell cycle progression through the S-M checkpoint. 4) overexpression of APPBP1 causes apoptosis via deregulation of NEDD8 conjugation. 5) binding of TP53BP2 to the regulatory subunit APPBP1 decreases neddylation activity 6) heterodimer of UBE1C & APPBP1, binds NEDD8 & UBE2M 7) binds APP & TP53BP2 Structure: - belongs to the ubiquitin-activating E1 family, ULA1 subfamily Compartment: - cell membrane - colocalizes with APP in lipid rafts Expression: - ubiquitous in fetal tissues - expressed throughout the adult brain Notes: - NAE1 & UBA3 correspond to the N-terminal & the C-terminal part of yeast UBA3 - in yeast the two subunits form a single polypeptide chain

Related

amyloid precursor protein (APP) or A4/beta amyloid precursor protein NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme E1C; ubiquitin-like modifier-activating enzyme 3; ubiquitin-activating enzyme 3 (UBA3, UBE1C) NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)

Properties

SIZE: entity length = 534 aa MW = 59 kD COMPARTMENT: plasma membrane MOTIF: ligand-binding site histidine residue {211} transmembrane domain binding site SITE: 331-344 FOR-BINDING-OF: NEDD8-activating enzyme E1 catalytic subunit

Database Correlations

OMIM 603385 UniProt Q13564 Pfam PF00899 Kegg hsa:8883

References

UniProt :accession Q13564