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appetite-regulating hormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide; M46 protein; contains: ghrelin-27, ghrelin-28, ghrelin, obestatin (GHRL, MTLRP, UNQ524/PRO1066)
Function:
- precursor of ghrelin, obestatin
- may be or give rise to growth hormone releasing peptide
Structure: belongs to the motilin family
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- highest level in stomach
- all forms are found in serum
Related
growth hormone-releasing hormone; somatotropin-releasing hormone,; somatocrinin; somatoliberin (GHRH)
obestatin (hexarelin)
Specific
ghrelin; ghrelin -27; ghrelin-28
General
peptide precursor
secreted protein
Properties
SIZE: entity length = 117 aa
MW = 13 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
PRECURSOR-FOR: ghrelin
obestatin
Database Correlations
OMIM 605353
MORBIDMAP 605353
UniProt Q9UBU3
PFAM correlations
Entrez Gene 51738
Kegg hsa:51738
References
- UniProt :accession Q9UBU3
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/GhrelinID327.html
- Protein Spotlight; Gut feelings - Issue 66 of January 2006
http://www.expasy.org/spotlight/back_issues/sptlt066.shtml
- Wikipedia; Ghrelin
http://en.wikipedia.org/wiki/Ghrelin