apoptotic chromatin condensation inducer in the nucleus; acinus (ACIN1, ACINUS, KIAA0670)

Function: - component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs - induces apoptotic chromatin condensation after activation by CASP3 - undergoes proteolytic cleavage - the processed form is active, in contrast to the inactive uncleaved form - forms heterodimers with RNPS1 - found in a heterotrimeric complex with ACIN1, RNPS1 & SAP18 - interacts with API5 Structure: contains 1 SAP domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: ubiquitous

Related

acinus of gland apoptosis

General

nuclear protein phosphoprotein pro apoptotic protein

Properties

SIZE: entity length = 1341 aa MW = 152 kD COMPARTMENT: cell nucleus MOTIF: SAP {72-106} glutamate-rich region {142-442} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S166} Ser phosphorylation site {S169} Ser phosphorylation site {S208} Ser phosphorylation site {S216} Ser phosphorylation site {S228} Ser phosphorylation site {S229} Ser phosphorylation site {S240} Ser phosphorylation site {S243} Thr phosphorylation site {T254} Ser phosphorylation site {S256} Thr phosphorylation site {T269} Ser phosphorylation site {S295} Ser phosphorylation site {S328} Ser phosphorylation site {S365} Ser phosphorylation site {S384} Ser phosphorylation site {S386} Ser phosphorylation site {S388} Thr phosphorylation site {T393} Ser phosphorylation site {S400} Thr phosphorylation site {T408} Ser phosphorylation site {S410} Thr phosphorylation site {T414} Ser phosphorylation site {S424} Ser phosphorylation site {S425} Ser phosphorylation site {S434} Ser phosphorylation site {S453} Ser phosphorylation site {S478} Ser phosphorylation site {S490} Tyr phosphorylation site {Y512} Ser phosphorylation site {S561} serine-rich region {573-676} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S655} Ser phosphorylation site {S657} Ser phosphorylation site {S661} Ser phosphorylation site {S664} Ser phosphorylation site {S675} Ser phosphorylation site {S676} Thr phosphorylation site {T682} Ser phosphorylation site {S710} Ser phosphorylation site {S714} Thr phosphorylation site {T720} Ser phosphorylation site {S729} Ser phosphorylation site {S814} Ser phosphorylation site {S815} Ser phosphorylation site {S825} Thr phosphorylation site {T830} Ser phosphorylation site {S838} Thr phosphorylation site {T840} Ser phosphorylation site {S895} Ser phosphorylation site {S898} Thr phosphorylation site {T976} Thr phosphorylation site {T978} Ser phosphorylation site {S981} Ser phosphorylation site {S983} Ser phosphorylation site {S987} Ser phosphorylation site {S990} Ser phosphorylation site {S1004} proteolytic site {1093-1094} proline-rich region SITE: 1114-1131 MOTIF: proline residue (SEVERAL) lysine-rich region {1132-1341} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S1176} Ser phosphorylation site {S1178} Ser phosphorylation site {S1180} Ser phosphorylation site {S1284} Ser phosphorylation site {S1329} Ser phosphorylation site {S1331} Thr phosphorylation site {T1332}

Database Correlations

OMIM 604562 UniProt Q9UKV3 Pfam PF02037 Entrez Gene 22985 Kegg hsa:22985

References

UniProt :accession Q9UKV3