apoptosis-stimulating of p53 protein 1; protein phosphatase 1 regulatory subunit 13B (PPP1R13B, ASPP1, KIAA0771)

Function: - role in regulation of apoptosis via its interaction with p53/TP53 - regulates TP53 by enhancing DNA binding & transactivation function of TP53 on promoters of proapoptotic genes in vivo - interacts with TP53 Structure: - the ankyrin repeats & the SH3 domain are required for specific interactions with TP53 - belongs to the ASPP family - contains 2 ANK repeats - contains 1 SH3 domain Compartment: - cytoplasm, nucleus - predominantly cytoplasmic - some fraction is nuclear Expression: - reduced expression in breast carcinomas expressing a wild-type TP53 protein Notes: - in contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1 - this name was given due to its similarity with a protein that binds to protein phosphatase 1

General

ankyrin repeat domain protein (ANKRD) phosphoprotein

Properties

SIZE: entity length = 1090 aa MW = 120 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: glutamine-rich region {132-292} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S332} Ser phosphorylation site {S335} proline-rich region SITE: 428-860 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S671} Ser phosphorylation site {S681} ankyrin repeat NAME: ankyrin repeat SITE: 920-952 ankyrin repeat NAME: ankyrin repeat SITE: 953-985 src homology 3 [SH3] domain SITE: 1019-1081

Database Correlations

OMIM 606455 UniProt Q96KQ4 PFAM correlations Entrez Gene 23368 Kegg hsa:23368

References

UniProt :accession Q96KQ4