apoptosis-resistant E3 ubiquitin protein ligase 1 (AREL1, KIAA0317)

Function: - E3 ubiquitin-protein ligase - accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester & directly transfers the ubiquitin to targeted substrates - inhibits apoptosis by ubiquitinating & targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 & SEPT4/ARTS which are released from mitochondrion into the cytosol following apoptotic - stimulation Structure: - contains 1 filamin repeat - contains 1 HECT domain (E6AP-type E3 ubiquitin-protein ligase domain) Compartment: - membrane (putative). cytoplasm, cytosol Alternative splicing: named isoforms=2

General

cytoskeletal protein glycoprotein membrane protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: entity length = 823 aa MW = 94 kD COMPARTMENT: cytoplasm MOTIF: transmembrane domain {2-22} filamin repeat {52-158} N-glycosylation site {N210} N-glycosylation site {N306} HECT domain {483-823} MOTIF: cysteine residue {C790}

Database Correlations

OMIM 615380 UniProt O15033 PFAM correlations Entrez Gene 9870 Kegg hsa:9870

References

UniProt :accession O15033