apoptosis-related protein 3; APR-3; p18 (APR3, ATRAID, C2orf28, HSPC013, UNQ214/PRO240)

Function: - may play a critical role in inducing cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway Structure: contains 1 EGF-like domain Compartment: - cell membrane; single-pass membrane protein Alternative promoter usage: - at least 2 isoforms produced by alternative promoter usage Alternative splicing: named isoforms=3 Expression: - weakly expressed in hematopoietic cell lines - up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines

General

apoptosis related protein glycoprotein membrane protein

Properties

SIZE: entity length = 229 aa MW = 25 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-30} N-glycosylation site {N44} N-glycosylation site {N79} EGF domain {152-193} MOTIF: cysteine residue {C156} MODIFICATION: cysteine residue {C171} N-glycosylation site {N157} cysteine residue {C165} MODIFICATION: cysteine residue {C181} N-glycosylation site {N168} cysteine residue {C171} MODIFICATION: cysteine residue {C156} cysteine residue {C181} MODIFICATION: cysteine residue {C165} cysteine residue {C183} MODIFICATION: cysteine residue {C192} cysteine residue {C192} MODIFICATION: cysteine residue {C183} transmembrane domain {200-220}

Database Correlations

UniProt Q6UW56 Entrez Gene 51374 Kegg hsa:51374

References

UniProt Q6UW56