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apoptosis inhibitor 5; API-5; antiapoptosis clone 11 protein; AAC-11; cell migration-inducing gene 8 protein; fibroblast growth factor 2-interacting factor; FIF; protein XAGL (API5)
Function:
- antiapoptotic factor
- protein assembly (putative)
- negatively regulates ACIN1
- by binding to ACIN1, suppresses ACIN1 cleavage from CASP3 & ACIN1-mediated DNA fragmentation
- suppresses E2F1-induced apoptosis
- depletion enhances the cytotoxic action of chemotherapy acetylation at Lys-251 impairs antiapoptotic function
- monomer
- interacts with FGF2 & ACIN1
Structure:
- two regions, an N-terminal (aa 96-107) & a C-terminal (aa 274-311) are required for binding FGF2
- belongs to the API5 family
Compartment:
- mainly nucleus, also cytoplasm
- isoform 3 is cytoplasmic
Alternative splicing:
- named isoforms=5
- additional isoforms seem to exist
Expression:
- expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas
- highest levels in heart, pancreas, placenta
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 524 aa
MW = 59 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: ARM-like and Heat-like helical repeats {2-360}
MOTIF: proline residue {2}
Tyr phosphorylation site {Y28}
leucine zipper
SITE: 370-391
FOR-BINDING-VIA: leucine zipper
nuclear translocation signal {454-475}
MOTIF: Ser phosphorylation site {S464}
Database Correlations
OMIM 609774
UniProt Q9BZZ5
Pfam PF05918
Entrez Gene 8539
Kegg hsa:8539
References
- UniProt :accession Q9BZZ5
- NIEHS-SNPs
http://egp.gs.washington.edu/data/api5/