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apoptosis-inducing factor-like protein (AIFL, AIFM3)
Function:
1) induces apoptosis through a caspase dependent pathway
- the Rieske domain induces apoptosis
2) reduces mitochondrial membrane potential
Structure:
1) belongs to the FAD-dependent oxidoreductase family
2) contains 1 Rieske domain
Compartment:
- mitochondrion
- does not translocate to the nucleus upon induction of apoptosis
Alternative splicing: named isoforms=4
Expression:
- ubiquitous
- expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland, tongue (at protein level)
General
metalloprotein
mitochondrial protein
oxidoreductase
Properties
SIZE: MW = 67 kD
entity length = 605 aa
COMPARTMENT: mitochondria
cell nucleus
MOTIF: RIESKE {68-161}
MOTIF: cofactor-binding site [109-109]
COFACTOR-BOUND: iron sulfur [FeS] cluster
cofactor-binding site [111-111]
COFACTOR-BOUND: iron sulfur [FeS] cluster
cofactor-binding site [128-128]
COFACTOR-BOUND: iron sulfur [FeS] cluster
cofactor-binding site [131-131]
COFACTOR-BOUND: iron sulfur [FeS] cluster
Database Correlations
UniProt Q96NN9
PFAM correlations
References
UniProt :accession Q96NN9