apolipoprotein O (protein FAM121B) (APOO FAM121B My025 UNQ1866/PRO4302)

Function: - promotes cholesterol efflux from macrophage cells - detected in HDL, LDL & VLDL - secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL - may be involved in myocardium-protective mechanisms against lipid accumulation Structure: - belongs to the apolipoprotein O family - O-glycosylated, glycosaminoglycan of chondroitin-sulfate Compartment: membrane, secreted Alternative splicing: named isoforms=2 Expression: - expressed in all tissues examined - up-regulated in diabetic heart

General

apolipoprotein glycoprotein membrane protein secreted protein

Properties

SIZE: MW = 22 kD entity length = 198 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-25} transmembrane domain {108-128} Ser glycosylation site {S162}

References

UniProt :accession Q9BUR5