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apolipoprotein F; apo-F; lipid transfer inhibitor protein; LTIP (APOF)
Function:
- minor apolipoprotein that associates with LDL
- inhibits cholesteryl ester transfer protein (CETP) activity & appears to regulate cholesterol transport
- associates, to a lesser degree, with VLDL, apo A1 & apo A2
Structure:
- O-glycosylated with core 1 or possibly core 8 glycans
Compartment: secreted
Expression:
- expressed by the liver & secreted into plasma
Note:
- uncertain whether Met-1 or Met-12 is the initiator
General
apolipoprotein
glycoprotein
Properties
SIZE: entity length = 326 aa
MW = 35 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-35}
N-glycosylation site {N118}
Thr glycosylation site {T274}
Database Correlations
OMIM 107760
UniProt Q13790
Entrez Gene 319
Kegg hsa:319
References
- UniProt :accession Q13790
- Entrez Gene :accession 319