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apolipoprotein-E gene
Basal expression of apo E is independent of LXR. LXRE enhancer element mediates lipid-inducibility of apo E gene in macrophages & adipocytes, but not hepatocytes. The apoE4 allele is associated with an increased risk of late onset Alzheimer's disease, the apoE2 allele may be protective. Cortical thickness is regions related to entorhinal cortex is lower in children & young adults with apoE4 allele. [3]
Related
apo E/C1 gene cluster
apolipoprotein E (APOE)
apolipoprotein E genotype
General
gene with TATA box
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: apolipoprotein E
LOCUS: human chromosome-19 Q13.1
MOTIF: LX response element (LXRE) (2)
CpG island {-72}
CpG island {-51}
TATA box
NAME: TATA box
intron (3)
exon (4)
References
- OMIM :accession 107741
- Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR,
Mangelsdorf DJ, Tontonoz P.
LXRs control lipid-inducible expression of the apolipoprotein
E gene in macrophages and adipocytes.
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):507-12.
Epub 2001 Jan 9.
PMID: 11149950 (LXRE)
- Shaw P, Lerch JP, Pruessner JC, Taylor KN, Rose AB,
Greenstein D, Clasen L, Evans A, Rapoport JL, Giedd JN.
Cortical morphology in children and adolescents with
different apolipoprotein E gene polymorphisms:
an observational study.
Lancet Neurol. 2007 Jun;6(6):494-500.
PMID: 17509484
Databases & Figures
OMIM 107741
MORBIDMAP 107741
ApoE allele frequencies