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apolipoprotein D; apo A3; apoA III; thin-line peptide (APOD APOA3)
Function:
- occurs in the macromolecular complex with LCAT
- primarily occurs in HDL (60-65%), with most of the remainder in VHDL & trace amounts in VLDL & LDL
- role in the transport of bilin
- able to transport a variety of ligands
Structure:
- homodimer
- in plasma, also exists as a disulfide-linked heterodimer with APOA2
Expression:
- expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain & tears
General
apolipoprotein
glycoprotein
lipocalin
oligomerizing protein
Properties
CONFIGURATION: dimer
SIZE: MW = 22.1 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C28}
MODIFICATION: cysteine residue {C134}
cysteine residue {C61}
MODIFICATION: cysteine residue {C185}
N-glycosylation site {N65}
N-glycosylation site {N98}
cysteine residue {C134}
MODIFICATION: cysteine residue {C28}
cysteine residue {C136}
MODIFICATION: cysteine residue {C136}
cysteine residue {C185}
MODIFICATION: cysteine residue {C61}
Database Correlations
OMIM 107740
UniProt P05090
Pfam PF00061
Entrez Gene 347
Kegg hsa:347
References
- Tietz Textbook of Clinical Chemistry, 2nd ed.
Burtis CA & Ashwood ER (eds), WB Saunders Co,
Philadelphia PA, 1993, pg 1023
- UniProt :accession P05090