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apolipoprotein B mRNA editing enzyme complex
Function:
- postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA
- apolipoprotein B mRNA editing results in formation of apo B48, rather than apo B100
- catalytic subunit, APOBEC1, binds to the mRNA & deaminate its target cytosine to uracil
- protects the edited APOB mRNA from nonsense-mediated decay
Structure:
- subunits include: APOBEC1, ACF
Expression: mRNA editing of apoB occurs in small intestine
Related
apolipoprotein B mRNA editing enzyme complex (GO:0030895)
General
molecular complex
Properties
SUBUNITS: apo B mRNA-editing protein
COMPARTMENT: cytoplasm
CELL: epithelial cell
WITHIN: small intestine
MOTIF: Zn+2-binding site
SITE: 61-61
glutamate residue {E63}
Zn+2-binding site
SITE: 93-93
Zn+2-binding site
SITE: 96-96
APOBEC1 complementation factor
COMPARTMENT: cytoplasm
cell nucleus
endoplasmic reticulum
MOTIF: RNP motif
NAME: RNP motif
SITE: 56-134
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
RNP motif
NAME: RNP motif
SITE: 136-218
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
RNP motif
NAME: RNP motif
SITE: 231-303
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
nuclear localization {360-409}
References
- UniProt :accession Q9NZI8
- Scott et al Current Opinion In Lipidology 5:87 1994
Components
apo B mRNA-editing protein (HEPR, APOBEC1)
APOBEC1 complementation factor; APOBEC1-stimulating protein; apo B mRNA-targeting protein (ACF, ASP, A1CF)