apolipoprotein A1 regulatory protein-1; transcription factor COUP 2; COUP-TF2; nuclear receptor subfamily 2 group F member 2; apolipoprotein AI regulatory protein 1 (ARP1, TFCOUP2, ARP-1, NR2F2)

Function: - regulation of the apolipoprotein A1 gene transcription - binds to DNA site A - interacts with SQSTM1 (putative) - binds DNA as a homodimer Structure: - belongs to the nuclear hormone receptor family, NR2 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus Expression: found in all tissues

General

DNA-binding protein transcription factor (TF) zinc finger protein

Properties

SIZE: entity length = 414 aa MW = 46 kD COMPARTMENT: cell nucleus MOTIF: glutamine-rich region {71-75} MOTIF: glutamine residue (SEVERAL) DNA-binding motif SITE: 76-151 MOTIF: Zn finger C4-type SITE: 79-99 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 115-139 EFFECTOR-BOUND: Zn+2 dimerization {337-414}

Database Correlations

OMIM 107773 UniProt P24468 PFAM correlations Kegg hsa:7026

References

UniProt :accession P24468