apical endosomal glycoprotein (MAM domain-containing protein 4, MAMDC4, AEGP, UNQ3001/PRO9742)

Function: - role in sorting & selective transport of receptors & ligands across polarized epithelia (putative) Structure: - contains 3 LDL-receptor class A domains - contains 6 MAM domains Compartment: membrane Alternative splicing: named isoforms=3

General

glycoprotein membrane protein

Properties

SIZE: MW = 131 kD entity length = 1216 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-22} LDL-receptor class A {26-53} MAM domain {64-222} MOTIF: cysteine residue {*1} (2) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (2) MODIFICATION: cysteine residue {*1} N-glycosylation site {N203} LDL-receptor class A {228-266} MOTIF: cysteine residue {C229} MODIFICATION: cysteine residue {C241} cysteine residue {C236} MODIFICATION: cysteine residue {C254} cysteine residue {C241} MODIFICATION: cysteine residue {C229} cysteine residue {C248} MODIFICATION: cysteine residue {C265} cysteine residue {C254} MODIFICATION: cysteine residue {C236} cysteine residue {C265} MODIFICATION: cysteine residue {C248} MAM domain {269-425} MOTIF: cysteine residue {*1} (2) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (2) MODIFICATION: cysteine residue {*1} N-glycosylation site {N281} N-glycosylation site {N339} LDL-receptor class A {456-491} MOTIF: cysteine residue {C457} MODIFICATION: cysteine residue {C468} cysteine residue {C464} MODIFICATION: cysteine residue {C481} cysteine residue {C468} MODIFICATION: cysteine residue {C457} cysteine residue {C475} MODIFICATION: cysteine residue {C490} cysteine residue {C481} MODIFICATION: cysteine residue {C464} cysteine residue {C490} MODIFICATION: cysteine residue {C475} MAM domain {491-644} MOTIF: cysteine residue {*1} (2) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (2) MODIFICATION: cysteine residue {*1} N-glycosylation site {N583} N-glycosylation site {N636} MAM domain {654-809} MOTIF: cysteine residue {*1} (2) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (2) MODIFICATION: cysteine residue {*1} MAM 5 {811-969} MOTIF: N-glycosylation site {N835} MAM 6 {971-1138} transmembrane domain {1152-1172}

Database Correlations

UniProt Q6UXC1 PFAM correlations

References

UniProt :accession Q6UXC1