apelin receptor early endogenous ligand; protein elabela; protein Toddler (APELA, ELA, TDL)

Function: - hormone required during early development for endoderm differentiation & heart morphogenesis - acts as a ligand for the apelin receptor (APLNR) & promotes its internalization - acts as a motogen by promoting endoderm & mesendoderm cell migration during gastrulation via the apelin receptor - role during heart development via the apelin receptor - interacts with APLNR (putative) Structure: - belongs to the elabela/Toddler family Compartment: - secreted, extracellular space Expression: - highest expression in undifferentiated embryonic stem cells - rapidly down-regulated during differentiation

General

glycoprotein receptor secreted protein

Properties

SIZE: entity length = 54 aa MW = 7 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-22} N-glycosylation site {N27}

Database Correlations

OMIM 615594 UniProt P0DMC3

References

UniProt :accession P0DMC3