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anti-Mullerian hormone type-2 receptor; anti-Mullerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII (AMHR2, AMHR)
Function:
- receptor for mullerian inhibitory factor
- on ligand binding, forms a receptor complex consisting of two type 2 & two type 1 transmembrane serine/threonine kinases
- type 2 receptors phosphorylate & activate type 1 receptors which autophosphorylate, then bind & activate SMAD transcriptional regulators
Cofactor: Mg+2 or Mn+2 (putative)
Structure:
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
- contains 1 protein kinase domain
Compartment: membrane
Pathology:
- defects in AMHR2 are the cause of persistent Mullerian duct syndrome type 2
General
cell surface receptor
glycoprotein
serine/threonine kinase
Properties
SIZE: entity length = 573 aa
MW = 63 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-17}
N-glycosylation site {N66}
N-glycosylation site {N119}
transmembrane domain {150-170}
kinase domain
SITE: 203-518
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 209-217
ATP-binding site
NAME: ATP-binding site
SITE: 230-230
aspartate residue {D333}
Database Correlations
OMIM correlations
UniProt Q16671
Pfam PF00069
Entrez Gene 269
Kegg hsa:269
ENZYME 2.7.11.30
References
- UniProt :accession Q16671
- Wikipedia; anti-mullerian hormone entry
http://en.wikipedia.org/wiki/anti-m%C3%BCllerian_hormone