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antineoplastic platinum complex; platinum-based chemotherapy
Adverse effects:
- ototoxicity
- sodium thiosulfate decreases risk of ototoxicity [3]
Mechanism of action:
- platinum complexes bind to & crosslink of DNA, which triggers apoptosis
Interactions
drug adverse effects of platinum-based chemotherapy
Specific
carboplatin (CDBCA, Paraplatin)
cisplatin (Platinol)
oxaliplatin (Eloxatin)
General
antineoplastic agent (chemotherapeutic agent)
References
- Kostova I
Platinum Complexes as Anticancer Agents
Recent Patents on Anti-Cancer Drug Discovery 2006, 1, 1-22
http://www.benthamscience.com/pra/samples/pra1-1/Kostova.pdf
- Wikipedia: Cisplatin
http://en.wikipedia.org/wiki/Cisplatin
- Chen CH, Huang CY, MD, PhD1,2; Haley Lin HYet al
Association of Sodium Thiosulfate With Risk of Ototoxic Effects From
Platinum-Based ChemotherapyA Systematic Review and Meta-analysis.
JAMA Netw Open. 2021;4(8):e2118895.
PMID: 34338793 PMCID: PMC8329743 Free PMC article
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2782575