Search
antimicrobial photodynamic therapy
Procedure:
- uses a photosensitizing drug & visible light has been used to kill bacteria, viruses, & fungi
- most photosensitizers show photodynamic activity against Gram-positive organisms
- for Gram-negative bacteria, cationic photosensitizers are needed
- phenothiazinium derivatives are cationic photosensitizers that absorb light in the 630-680 nm range
- ultraviolet radiation with germicidal lamps (ultraviolet C spectrum) has also been used to treat chronic leg ulcers
General
phototherapy
References
- Morley S et al.
Phase IIa randomised, placebo-controlled study of antimicrobial
photodynamic therapy in bacterially colonised, chronic
leg ulcers and diabetic foot ulcers: A new approach to
antimicrobial therapy.
Br J Dermatol 2012 Oct 15;
PMID: 23066973