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antileukoproteinase; ALP; BLPI; HUSI-1; mucus proteinase inhibitor; MPI; protease inhibitor WAP4; secretory leukocyte protease inhibitor; seminal proteinase inhibitor; WAP four-disulfide core domain protein 4 (SLPI, WAP4, WFDC4)
Function:
- acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, & cathepsin G
- may prevent elastase-mediated damage to oral & possibly other mucosal tissues
Structure: contains 2 WAP domains
Compartment: secreted
Expression: mucous fluids
Pathology:
- respiratory tract disease may involve an imbalance between proteases of cells involved in inflammatary responses & the inhibitors of these proteases
- inflammation-mediated release of neutrophil elastase in the lungs of patients whose levels of active alpha-1-antiprotease are compromised by genetic background, cigarette smoking, air pollutants, or a combination of all three can result in severe lung damage & a increased mortality
Pharmacology:
- the relatively small size of SLPI, its lack of glycosylation & its stability make this protein a candidate for use as a therapeutic agent in diseases mediated by leukocyte elastase-antielastase imbalances
General
protease inhibitor
secreted protein
Properties
SIZE: entity length = 132 aa
MW = 14 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
Trypsin inhibitory {26-83}
MOTIF: WAP 1 {28-76}
cysteine residue {C35}
MODIFICATION: cysteine residue {C64}
cysteine residue {C43}
MODIFICATION: cysteine residue {C68}
peptide motif {45-46}
cysteine residue {C51}
MODIFICATION: cysteine residue {C63}
cysteine residue {C57}
MODIFICATION: cysteine residue {C72}
cysteine residue {C63}
MODIFICATION: cysteine residue {C51}
cysteine residue {C64}
MODIFICATION: cysteine residue {C35}
cysteine residue {C68}
MODIFICATION: cysteine residue {C43}
cysteine residue {C72}
MODIFICATION: cysteine residue {C57}
WAP 2 {82-130}
Elastase inhibitory {84-132}
MOTIF: cysteine residue {C89}
MODIFICATION: cysteine residue {C118}
cysteine residue {C96}
MODIFICATION: cysteine residue {C122}
peptide motif {97-98}
cysteine residue {C105}
MODIFICATION: cysteine residue {C117}
cysteine residue {C111}
MODIFICATION: cysteine residue {C126}
cysteine residue {C117}
MODIFICATION: cysteine residue {C105}
cysteine residue {C118}
MODIFICATION: cysteine residue {C89}
cysteine residue {C122}
MODIFICATION: cysteine residue {C96}
cysteine residue {C126}
MODIFICATION: cysteine residue {C111}
INHIBITS: protease
Database Correlations
OMIM 107285
UniProt P03973
Pfam PF00095
Entrez Gene 6590
Kegg hsa:6590
References
- UniProt :accession P03973
- Entrez Gene :accession 6590