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antihypertensive combination

Notes: - fixed combinations of antihypertensives offer less flexibility in dosing & are often more expensive than the component medications prescribed individually [4]

Interactions

drug interactions

Specific

ACE inhibitor/calcium channel blocker ACE inhibitor/diuretic adrenergic receptor antagonist/diuretic aliskiren/amlodipine/hydrochlorothiazide (Amturnide) aliskiren/hydrochlorothiazide (Tekturna HCT) aliskiren/valsartan (Valturna) alpha-1-receptor blocker/diuretic amiloride/furosemide amiloride/hydrochlorothiazide; amiloride/HCTZ (Moduretic) amlodipine/benazepril (Lotrel) amlodipine/celecoxib (Consensi) amlodipine/hydrochlorothiazide/olmesartan (Tribenzor) amlodipine/hydrochlorothiazide/valsartan amlodipine/indapamide/telmisartan amlodipine/olmesartan (Azor) amlodipine/telmisartan (Twynsta) amlodipine/valsartan (Exforge) angiotensin II receptor antagonist/calcium channel blocker angiotensin II receptor antagonist/calcium channel blocker/diuretic angiotensin II receptor antagonist/diuretic atenolol/chlorthalidone (Tenoretic) azilsartan/chlorthalidone (Edarbyclor, Takeda) benazepril/hydrochlorothiazide; benazepril/HCTZ (Lotensin HCTZ) bendroflumethiazide/nadolol (Corzide) beta-adrenergic receptor antagonist/calcium channel blocker beta-adrenergic receptor antagonist/diuretic bisoprolol/hydrochlorothiazide; bisoprolol/HCTZ (Ziac) captopril/hydrochlorothiazide; captopril/HCTZ (Capozide) central alpha-2 agonist/diuretic chlorothiazide/methyldopa (Aldoclor) chlorthalidone/clonidine (Combipres) combination of ACE inhibitor/angiotension 2 receptor antagonist diuretic/postganglionic blocker diuretic/potassium diuretic/renin inhibitor diuretic/vasodilator enalapril/diltiazem (Teczem) enalapril/felodipine (Lexxel) enalapril/hydrochlorothiazide; enalapril/HCTZ (Vaseretic) guanethidine/hydrochlorothiazide; guanethidine/HCTZ (Esmil) hydralazine/hydrochlorothiazide/reserpine; hydralazine/HCTZ/reserpine (Ser Ap Es) hydralazine/hydrochlorothiazide; hydralazine/HCTZ (Apresazide) hydralazine/isosorbide dinitrate (BiDiL) hydrochlorothiazide/irbesartan (Avalide) hydrochlorothiazide/lisinopril; HCTZ/lisinopril (Prinzide, Zestoretic) hydrochlorothiazide/losartan; HCTZ/losartan (Hyzaar) hydrochlorothiazide/methyldopa; HCTZ/methyldopa (Aldoril) hydrochlorothiazide/metoprolol; HCTZ/metoprolol (Lopressor HCTZ, Dutoprol) hydrochlorothiazide/moexipril hydrochlorothiazide/olmesartan (Benicar HCT) hydrochlorothiazide/propranolol; HCTZ/propranolol (Inderide) hydrochlorothiazide/quinapril hydrochlorothiazide/spironolactone; HCTZ/spironolactone (Aldactazide) hydrochlorothiazide/telmisartan hydrochlorothiazide/timolol; HCTZ/timolol (Timolide) hydrochlorothiazide/triamterene; HCTZ/triamterene (Dyazide, Maxzide, Maxide) hydrochlorothiazide/valsartan Minizide (prazosin/polythiazide) reserpine/thiazide trandolapril/verapamil (Tarka)

General

pharmacologic combination

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Prescriber's Letter 20(4): 2013 Antihypertensive Combinations Detail-Document#: 290421 (subscription needed) http://www.prescribersletter.com
  3. Gradman AH, Basile JN, Carter BL, et al. Combination therapy in hypertension. J Am Soc Hypertens 2010;4:42-50. PMID: 20374950
  4. Medical Knowledge Self Assessment Program (MKSAP) 11, 15, 16. American College of Physicians, Philadelphia 1998, 2009, 2012

Components

antihypertensive agent