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CD80, antigen-presenting cell B7-1, B-lymphocyte activation antigen B7-1, or BB1
Function:
- immunoglobulin-like molecule on the surface of antigen-presenting cells
- role in autoimmune, humoral & transplant responses
- co-regulates T cell activation with CD86
- ligand for
- CD28 on T-cells; interaction of CD28 is necessary in addition to stimulation of the T-cell receptor for production of IL-2 in quiescent T-cells
- CD152
Expression:
- activated B cells
- activated T cells
- macrophages
- dendritic cells
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
immunoglobulin superfamily protein
Properties
COMPARTMENT: plasma membrane
CELL: antigen-presenting cell
MOTIF: glycosylation site
immunoglobulin superfamily domain
transmembrane domain
Database Correlations
OMIM 112203
UniProt P33681
Entrez Gene 941
References
- Pawson T.
Protein modules and signalling networks.
Nature. 1995 Feb 16;373(6515):573-80. Review.
PMID: 7531822
- Entrez Gene :accession 941
- http://www.pathologyoutlines.com/cdmarkers.html
20 May 2003
- Protein Reviews on the Web
http://mpr.nci.nih.gov/prow/guide/642335762_g.htm
- Uniprot :accession P33681