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anticholinergic toxicity
also see anticholinergic agent
Clinical manifestations:
- average onset < 12 hours
- confusion, delirium, agitation
- flushing
- anhidrosis
- mydriasis
- hallucinations
- hyperthermia, < 102.2 F (39 C) [2]
- tachypnea & tachycardia common
- hypertension [2]
- hypoactive bowel sounds
- reflexes, muscle tone normal
Management:
- physostigmine
- if source known
- do not use if source unknown
- specifically contraindicated with tricyclic antidepressants
Related
parasympatholytic (anticholinergic, antimuscarinic agent)
General
toxicity; poisoning; overdose
References
- NEJM Knowledge+ Question of the Week. June 5, 2018
https://knowledgeplus.nejm.org/question-of-week/1826/
- Sinert RH
Fast Five Quis: Serotonin Syndrome
Medscape. 2121. June 4.
https://reference.medscape.com/viewarticle/951841
- Boyer EW, Shannon M.
The serotonin syndrome.
N Engl J Med. 2005 Mar 17;352(11):1112-20
PMID: 15784664 Review
https://www.nejm.org/doi/10.1056/NEJMra041867