Search
antiarrhythmic agent, Group IV
Indications:
- supraventricular tachycardia
- rate control of atrial arrthymias
- atrial fibrillation/atrial flutter
- triggered arrhythmias
Mechanism of action:
- slows SA node automaticity & AV node conduction
- class IV agents are Ca+2-channel blockers
- they selectively block the slow inward Ca+2 current, especially of the SA node, the AV node, & areas of diseased myocardium dependent upon slow Ca+2-channel activity for conduction, attenuating conduction velocity & automaticity & prolonging refractoriness of these structures
Interactions
drug interactions
Related
calcium channel blocker (CCB)
Specific
diltiazem (Cardizem, Dilacor, Tiazac, Cartia, Angiotrofin, Dilcontin)
verapamil (Isoptin, Calan, Verelan, Covera-HS, Iproveratril, Dilacorin, Cardioprotect)
General
antiarrhythmic agent
References
- Manual of Medical Therapeutics, 28th ed, Ewald &
McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 161
- Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17.
American College of Physicians, Philadelphia 2009, 2012, 2015
- Deprecated Reference