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antiarrhythmic agent, Group IC
Indications:
- atrial fibrillation
- atrial flutter
- suproventricular tachycardia
- ventricular arrhythmias
- chemical cardioversion [3]
Contraindications:
- class Ic agents should not be used in patients with structural heart disease because of their proarrhythmic potential, including widening of the QRS complex
Mechanism of action:
- markedly slows conduction, slightly prolongs repolarization
- class Ic antiarrhythmic agents have little effect on repolarization
- they possess local anesthetic & membrane stabilizing properties characteristic of all class I agents
- class Ic agents have potent effects on inhibition of Na+ influx during phase 0 of the fast sodium channel action potential
Interactions
drug interactions
drug adverse effects of antiarrhythmic agent, Group IC
Specific
dofetilide (Tikosyn)
encainide (Enkaid)
flecainide (Tambocor)
ibutilide (Corvert)
propafenone (Rythmol, Baxarytmon)
General
antiarrhythmic agent, Group I
References
- Manual of Medical Therapeutics, 28th ed, Ewald &
McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 150, 157
- Medical Knowledge Self Assessment Program (MKSAP) 15, 16.
American College of Physicians, Philadelphia 2009, 2012
- Deprecated Reference