antiarrhythmic agent, Group I

Class I agents have local anesthetic & membrane stabilizing properties through inhibition of Na⁺ influx during phase 0 of the fast sodium channel action potential. Class I agents are further classified into Ia, Ib & 1c based upon their effects on conduction & refractoriness.

Specific

antiarrhythmic agent, Group IA antiarrhythmic agent, Group IB antiarrhythmic agent, Group IC

References

Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 150