Contents

Search

anthralin (Lasan, Anthra-Derm, Drithocreme)

Tradenames: Lasan, Anthra-Derm, Drithocreme. Indications: - psoriasis - alopecia areata [4] Dosage: topical: apply QID. Ointment: 0.1%, 0.25%, 0.4%, 0.5%. Cream: 0.1%, 0.2%, 0.25%, 0.4%, 0.5%, 1%. Adverse effects: 1) not common (1-10%) - transient primary irritation of uninvolved skin - temporary discoloration of hair & fingernails - may stain skin, hair, fabrics 2) uncommon (< 1%) - rash, excessive irritation Mechanism of action: - anthralin is an unstable molecule, with an oxidizing center at C10 (center ring para to C=0 - oxidation leads to violet-brown discoloration of clothing - the mechanism of the effect of anthralin in psoriasis is unknown, but it inhibits mitochondrial electron transport

General

hydrocarbon ketone phenol

Properties

MISC-INFO: pregnancy-category C safety in lactation -

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996 pg 1608
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Department of Veterans Affairs, VA National Formulary
  4. Deprecated Reference