ANP receptor-C; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide C-type receptor; ANPRC; ANP-C; NPR-C (NPR3 ANPRC)

Function: - receptor for natriuretic peptide hormones - has broad specificity & can bind several distinct natriuretic peptides, including a) atrial natriuretic peptide (NPPA) b) brain natriuretic peptide (NPPB) - does not have guanylate cyclase activity - probably responsible for the clearance of natriuretic peptides from the circulation without a role in signal transduction - low affinity for peptide hormones in the absence of bound chloride Structure: - homodimer; disulfide-linked - dimers can also be formed through the C-terminal Cys of isoform 2 - belongs to the ANF receptor family Compartment: membrane Alternative splicing: named isoforms=2

General

glycoprotein natriuretic peptide receptor phosphoprotein

Properties

SIZE: entity length = 541 aa MW = 60 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-26} N-glycosylation site {N86} binding site SITE: 106-106 FOR-BINDING-OF: Chloride cysteine residue {C108} MODIFICATION: cysteine residue {C136} binding site SITE: 135-135 FOR-BINDING-OF: Chloride; via amide nitrogen binding site SITE: 136-136 FOR-BINDING-OF: Chloride; via amide nitrogen MOTIF: cysteine residue {C136} MODIFICATION: cysteine residue {C108} cysteine residue {C213} MODIFICATION: cysteine residue {C261} cysteine residue {C261} MODIFICATION: cysteine residue {C213} N-glycosylation site {N293} N-glycosylation site {N394} cysteine residue {C473} MODIFICATION: cysteine residue {C-INTERCHAIN} transmembrane domain {482-504} Ser phosphorylation site {S533}

Database Correlations

OMIM 108962 UniProt P17342 Pfam PF01094 Kegg hsa:4883

References

UniProt :accession P17342