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anorexia-cachexia syndrome
Etiology:
- HIV1 infection, AIDS
- metastatic cancer
Clinical manifestations:
- anorexia
- cachexia
Management:
- appetite stimulants do not improve morbidity or mortality (see anorexia) [3]
- artificial nutrition does not improve morbidity or mortality [3]
- olanzapine may improve appetite, weight & quality of life in patients with metastatic cancer [4]
General
anorexia
cachexia
syndrome
References
- Geriatric Review Syllabus, 9th edition (GRS9)
Medinal-Walpole A, Pacala JT, Porter JF (eds)
American Geriatrics Society, 2016
- Ruiz Garcia V et al
Megestrol acetate for treatment of anorexia-cachexia syndrome.
Cochrane Database Syst Rev. 2013 Mar 28;(3):CD004310. Review.
PMID: 23543530
- Medical Knowledge Self Assessment Program (MKSAP) 19
Board Basics. An Enhancement to MKSAP19.
American College of Physicians, Philadelphia 2022
- Sandhya L et al.
Randomized double-blind placebo-controlled study of olanzapine for chemotherapy-
related anorexia in patients with locally advanced or metastatic gastric,
hepatopancreaticobiliary, and lung cancer.
J Clin Oncol 2023 May 10; 41:2617
PMID: 36977285 Clinical Trial.
https://ascopubs.org/doi/10.1200/JCO.22.01997
- Roeland EJ, Bohlke K, Baracos VE et al
Cancer Cachexia: ASCO Guideline Rapid Recommendation Update.
J Clin Oncol. 2023 Sep 1;41(25):4178-4179.
PMID: 37467399