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annexin A5, annexin V, endonexin-2, lipocortin-5, vascular anticoagulant alpha (VAC-alpha), anchorin-C2, thromboplastin inhibitor, calphobindin-1, placental anticoagulant protein-1 (PAP-I)

Function: - anticoagulant protein - acts as an indirect inhibitor of thromboplastin - binds ATRX & EIF5B (putative) Structure: - monomer - a pair of annexin repeats may form one binding site for Ca+2 & phospholipid - belongs to the annexin family - contains 4 annexin repeats - 3D structure described in [2] - almost entirely alpha-helical - each of the 4 repeats is folded into a compact domain of similar structure Note: - independently sequenced by at least 7 groups under different names

Interactions

molecular events

General

annexin

Properties

MOTIF: Ca+2-binding site (5) binding site FOR-BINDING-OF: phospholipid annexin repeat (4) MOTIF: alpha helix (5)

Database Correlations

OMIM 131230 UniProt P08758 Pfam PF00191 Entrez Gene 308 Kegg hsa:308

References

  1. Rojas E, Pollard HB, Haigler HT, Parra C, Burns AL. Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes. J Biol Chem. 1990 Dec 5;265(34):21207-15. PMID: 2174439
  2. Huber R, Berendes R, Burger A, Luecke H, Karshikov A. Annexin V-crystal structure and its implications on function. Behring Inst Mitt. 1992 Apr;(91):107-25. Review. PMID: 1388018
  3. UniProt :accession P08758
  4. R&D systems' cytokine source book: annexin V http://www.rndsystems.com/molecule_detail.aspx?m=1063

Component-of

molecular complex