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annexin A2-like protein; annexin A2 pseudogene 2; lipocortin II pseudogene (ANXA2P2, ANX2L2, ANX2P2, LPC2B)
Function:
- Ca+2-regulated membrane-binding protein whose affinity for Ca+2 is greatly enhanced by anionic phospholipids (putative)
- binds two Ca+2 with high affinity
- may be involved in heat-stress response
- may cross-link plasma membrane phospholipids with actin & the cytoskeleton & be involved with exocytosis
Structure:
- pair of annexin repeats may form one binding site for Ca+2 & phospholipid (putative)
- heterotetramer containing 2 light chains of S100A10/p11 & 2 heavy chains of ANXA2P2/p36 (putative)
- belongs to the annexin family
- contains 4 annexin repeats
Compartment:
- secreted, extracellular space, extracellular matrix, basement membrane (putative)
- melanosome
- in the lamina beneath the plasma membrane
- in melanosome fractions from stage I to stage IV
- translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism (putative)
Note: could be the product of a pseudogene
General
Ca+2 binding protein
phosphoprotein
secreted protein
Properties
SIZE: entity length = 339 aa
MW = 39 kD
COMPARTMENT: cytoplasm
golgi
MOTIF: binding site
SITE: 2-24
FOR-BINDING-OF: S100-A10 protein
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S18}
Thr phosphorylation site {T19}
Tyr phosphorylation site {Y24}
Ser phosphorylation site {S26}
Tyr phosphorylation site {Y30}
Annexin {37-102}
Annexin {109-174}
Tyr phosphorylation site {Y188}
Annexin {193-259}
Annexin {269-334}
Database Correlations
UniProt A6NMY6
Pfam PF00191
References
UniProt :accession A6NMY6