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ankyrin repeat family A protein 2 (RFXANK-like 2, ANKRA2, ANKRA)
Function:
- endocytosis
- links megalin to cytoskeleton or endocytic machinery
- interacts with cytoplasmic tail of LRP2/megalin, HDAC4, HDAC5, & HDAC9
- all these interactions occur via recognition of a PxLPxI/L motif
- interacts with AHRR
- interacts with NEK6
Structure:
- 3 central ANK repeats mediate binding to the PxLPxI/L motif of interactors
- contains 5 ANK repeats
Compartment:
- cytoplasm, cytoskeleton
- peripheral membrane
General
ankyrin repeat domain protein (ANKRD)
Properties
SIZE: MW = 34 kD
entity length = 313 aa
COMPARTMENT: cytoplasm
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 181-213
ankyrin repeat
NAME: ankyrin repeat
SITE: 214-246
ankyrin repeat
NAME: ankyrin repeat
SITE: 247-279
Database Correlations
OMIM 605787
UniProt Q9H9E1
PFAM correlations
Entrez Gene 57763
Kegg hsa:57763
References
UniProt :accession Q9H9E1