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ankyrin repeat domain-containing protein 6; diversin (ANKRD6, KIAA0957)
Function:
- recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 & GSK3-beta & allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals (putative)
- interacts with AXN1, AXN2 & CSNK1E/CKI-epsilon
Structure: contains 8 ANK repeats
Alternative splicing: named isoforms=3
General
ankyrin repeat domain protein (ANKRD)
Properties
SIZE: entity length = 727 aa
MW = 80 kD
COMPARTMENT: cytoplasm
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 9-38
ankyrin repeat
NAME: ankyrin repeat
SITE: 41-70
ankyrin repeat
NAME: ankyrin repeat
SITE: 74-103
ankyrin repeat
NAME: ankyrin repeat
SITE: 107-136
ankyrin repeat
NAME: ankyrin repeat
SITE: 140-169
ankyrin repeat
NAME: ankyrin repeat
SITE: 173-202
ankyrin repeat
NAME: ankyrin repeat
SITE: 206-235
ankyrin repeat
NAME: ankyrin repeat
SITE: 239-268
proline-rich region
SITE: 382-385
MOTIF: proline residue (SEVERAL)
coiled coil {417-446}
coiled coil {682-727}
Database Correlations
OMIM 610583
UniProt Q9Y2G4
Pfam PF00023
Entrez Gene 22881
Kegg hsa:22881
References
UniProt :accession Q9Y2G4