serine/threonine protein phosphatase 6 regulatory ankyrin repeat subunit A; PP6-ARS-A; serine/threonine protein phosphatase 6 regulatory subunit ARS-A; ankyrin repeat domain-containing protein 28; phosphatase interactor targeting protein hnRNP K; PITK (ANKRD28 KIAA0379)

Function: - putative regulatory subunit of protein phosphatase 6 (PP6) - may be involved in the recognition of phosphoprotein substrates - role in PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha - selectively inhibits the phosphatase activity of PPP1C - targets PPP1C to modulate HNRPK phosphorylation - interacts with PPP1C & HNRPK - interacts with PPP6C, PPP6R1 & PPP6R3 Structure: contains 27 ANK repeats Compartment: - nucleus, nucleoplasm - seems to be excluded from nucleoli Alternative splicing: named isoforms=2

General

ankyrin repeat domain protein (ANKRD) enzyme regulatory subunit nuclear protein phosphoprotein

Properties

SIZE: entity length = 1086 aa MW = 117 kD COMPARTMENT: cell nucleus MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 73-102 ankyrin repeat NAME: ankyrin repeat SITE: 106-135 MOTIF: Ser phosphorylation site {S117} ankyrin repeat NAME: ankyrin repeat SITE: 139-168 ankyrin repeat NAME: ankyrin repeat SITE: 172-201 ankyrin repeat NAME: ankyrin repeat SITE: 205-234 ankyrin repeat NAME: ankyrin repeat SITE: 238-267 ankyrin repeat NAME: ankyrin repeat SITE: 271-300 ankyrin repeat NAME: ankyrin repeat SITE: 304-334 ankyrin repeat NAME: ankyrin repeat SITE: 338-367 ankyrin repeat NAME: ankyrin repeat SITE: 371-400 ankyrin repeat NAME: ankyrin repeat SITE: 404-433 ankyrin repeat NAME: ankyrin repeat SITE: 437-466 ankyrin repeat NAME: ankyrin repeat SITE: 470-499 ankyrin repeat NAME: ankyrin repeat SITE: 503-533 ankyrin repeat NAME: ankyrin repeat SITE: 537-567 ankyrin repeat NAME: ankyrin repeat SITE: 582-611 ankyrin repeat NAME: ankyrin repeat SITE: 615-644 ankyrin repeat NAME: ankyrin repeat SITE: 649-678 ankyrin repeat NAME: ankyrin repeat SITE: 685-714 ankyrin repeat NAME: ankyrin repeat SITE: 718-747 ankyrin repeat NAME: ankyrin repeat SITE: 751-780 ankyrin repeat NAME: ankyrin repeat SITE: 788-817 ankyrin repeat NAME: ankyrin repeat SITE: 820-850 ankyrin repeat NAME: ankyrin repeat SITE: 855-884 ankyrin repeat NAME: ankyrin repeat SITE: 888-918 ankyrin repeat NAME: ankyrin repeat SITE: 922-951 ankyrin repeat NAME: ankyrin repeat SITE: 958-987 Ser phosphorylation site {S1040} Ser phosphorylation site {S1044}

Database Correlations

OMIM 611122 UniProt O15084 Pfam PF00023 Entrez Gene 23243 Kegg hsa:23243

References

UniProt :accession O15084