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ankyrin repeat domain-containing protein 12; ankyrin repeat-containing cofactor 2; GAC-1 protein (ANKRD12, ANCO2, KIAA0874)
Function:
- may recruit HDACs to the p160 coactivators - nuclear receptor complex to inhibit ligand-dependent transactivation
- interacts with the PAS region of the p160 coactivators
Structure: contains 3 ANK repeats
Compartment: nucleus
Alternative splicing: named isoforms=2
General
ankyrin repeat domain protein (ANKRD)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 2062 aa
MW = 236 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S149}
ankyrin repeat
NAME: ankyrin repeat
SITE: 184-213
ankyrin repeat
NAME: ankyrin repeat
SITE: 217-246
ankyrin repeat
NAME: ankyrin repeat
SITE: 250-280
Ser phosphorylation site {S861}
Database Correlations
OMIM 610616
UniProt Q6UB98
PFAM correlations
Entrez Gene 23253
Kegg hsa:23253
References
UniProt :accession Q6UB98